Este jueves 4 de julio de 2019 a las 13hs en el Aula del IMMF, el Becario Doctoral Foncyt, Cristian Bacaglio dictará el seminario “MOLECULAR MECHANISMS ASSOCIATED WITH IMPAIRED PERIPHERAL NERVE REPAIR MEDIATED BY ANTI-GANGLIOSIDE ANTIBODIES”
Resumen: Guillain Barré Syndrome (GBS) is an acute monophasic polyneuropathy characterized by the presence of ascending muscular paralysis and arreflexia. In a subgroup of patients, paralysis is associated to the presence of high titers of antibodies targeting gangliosides (anti-Gg). Passive transfer studies with a mAb anti-Gg (anti GD1a-GT1b, clone 1b7) in a murine model of axon regeneration confirmed that these antibodies are able to inhibit nerve repair by negative modulation of actin and tubulin cytoskeleton at growth cones. However, recent findings from our lab in this model show that nerves from animals exposed to anti-Gg display a significant failure in the clearance of tissue debris, suggesting a possible effect on non-neural cells. Thus, we observed that mice treated with 1b7 after a nerve crush display an alteration in the number/phenotype of infiltrating macrophages in the sciatic nerve compared to control nerves. Furthermore, we discuss briefly the role of Rho-A signaling pathways in the process of nerve repair, focusing on non-neural cells. In conclusion, these results suggest the effect of anti-Gg on nerve repair by targeting non-neural cells in addition to halt axon regeneration by targeting growth cones.