Cáceres Laboratory 

Dr. Alfredo Cáceres                     

 

Was born in 1952 in Córdoba, Argentina. He graduated as a physician in 1975 from the School of Medicine (National University of Córdoba) and obtained a PhD in Medicine (1979) from the same University supervised by Dr. Samuel Taleisnik. At the Instituto Mercedes Martín Ferreyra (INIMEC-CONICET-UNC). He did postdoctoral work (1980-1982) with Dr. Oswald Steward (University of Virginia, Charlottesville, Virginia, USA) and Dr. Gary A. Banker (Albany Medical College, New York, USA) work that establish the existence of fundamental differences in the organization of the axonal and dendritic cytoskeleton and lead to the concept of neuronal polarity. Since 1982 he is a member of the National Research Council of Argentina (CONICET) and currently the Director of the Instituto Investigación Médica Mercedes Martín Ferreyra (INIMEC-CONICET-UNC). He has been a Visiting Scientist at the Center Neurological Diseases (Harvard Medical School, Boston, USA, 1989-1990), Visiting Professor at the Dyson Vision Institute (Cornell Medical College, NYC, USA, 2003-2004) and at the Max Plank Institute of Biophysical Chemistry (Göttingen, Germany, 2014). From 1997 to 2006 he was an International Research Scholar of the Howard Hughes Medical Institute (HHMI) and in 2018 was elected Associate Member of the European Molecular Biology Organization (EMBO). He has received several awards and prizes including the Fogarty International Fellowship (1980), the Guggenheim Fellowship (2002), the Alexander von Humboldt Research Award (2013) and the Konex Award (2013). He has published more than 90 articles in international peer-reviewed journal, supervised 15 PhD theses, many undergraduate students and postdoctoral fellows. He is a member of the Society of Neuroscience (SfN, USA), the American Society of Cell Biology (ASCB, USA) and the Argentine Society of Neuroscience, where he served as Vice-President.

The research of Dr. Cáceres group seeks to obtain insignhts about the participation of cytoskeletal proteins in the development of neuronal polarity. A combination of cellular and molecular biology procedures, including advanced imaging techniques in living cells, is currently being used in his laboratory. Neurons are highly polarized cells capable of generating a long axon and several highly branched dendrites. Axons and dendrites differ in their cytoskeleton components, distribution of organelles, membrane proteins, and their function. The knowledge of the cellular and molecular mechanisms involved in the development and maintenance of neuronal polarity is fundamental to understand how the nervous circuits are generated and how they function. This information is also of great importance to understand the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's. During the last 30 years, our research group has been dedicated to study the role of the cytoskeleton and signaling pathways (e.g., small RhoGTPases: RhoA, Rac, Cdc42, etc.) in the establishment of neuronal polarity. At present, we study the organization and dynamics of microtubules, actin filaments, and RhoA during axonal formation using multidimensional microscopy and nanoscopy (STED, STORM). We also study the biogenesis of membrane organelles, such as dendritic mini-Golgi apparatuses (GOPs) and the regulation of the differential traffic of membrane proteins to axons and dendrites. Finally, we studied the morpho-dynamics events of neuronal polarization in embryonic stem cells of murine origin and in iPSCs ("Induced Pluripotent Stem Cells") obtained from normal individuals and with genetic variants associated with Alzheimer's disease.

acaceres@immf.uncor.edu

See more…

 

Associate Researchers

           Dr. Agustín Anastasía

 

Dr. Agustin Anastasia is a biologist (2004) and PhD (2009), graduated from the National University of Córdoba. His doctoral studies were conducted under the direction of Dr. Daniel H. Masco at the Centro de Biología Celular y Molecular (CeBiCeM, National University of Córdoba) with a CONICET fellowship. During his PhD, Dr. Anastasia studied neuroprotection mechanisms of the nigrostriatal dopaminergic system induced by enriched environment and electro-convulsive therapy. In 2010, he emigrated to the United States where he carried out postdoctoral training for 5 years in the laboratory of Dr. Barbara L. Hempstead at Weill Cornell Medical College in New York. His studies were carried out in collaboration with Dr. Francis S. Lee and Dr. Moses V. Chao. His research focused on clarifying the activation mechanisms of the neurotrophin receptor p75NTR and the study of a single nucleotide polymorphism (SNP) in the BDNF gene that is highly associated with an increased risk to develop psychiatric and neurodegenerative diseases. In 2015 Dr. Anastasia returned to Argentina as CONICET (National Research Council) Researcher and established his laboratory at the Instituto Ferreyra (INIMEC-CONICET-Universidad Nacional de Córdoba). Dr. Anastasia is a Professor of Neurophysiology and Psychophysiology at the School of Psychology (Universidad Nacional de Córdoba), and Professor of Cell Biology at the Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC).

aanastasia@immf.uncor.edu

See More... 

             Dr. Mariano Bisbal

El Dr. Mariano Bisbal obtuvo su título de grado como Biólogo en la Facultad de Ciencias Exactas, Físicas y Naturales de la Universidad Nacional de Córdoba, Argentina y completó sus estudios obteniendo el título de Doctor en Ciencias Biológicas en la misma universidad. Luego se trasladó a Grenoble, Francia, donde llevó a cabo dos estadías post-doctorales en el Instituto de Neurociencias de Grenoble (Grenoble Institute des Neuroscience–INSERM (2009-2013)) bajo la mentoríade la Dra Catherine Villard y la Dra. AnnieAndrieux. Durante este periodo realizó estudios relacionados con el desarrollo de la polaridad neuronal utilizando técnicas de micropatrones de sustrato y, en segundo lugar, investigó el rol funcional de la proteína de unión a microtúbulos MAP6, especialmente en la formación de espinas dendríticas. En el año 2013 se incorpora al laboratorio de Neurobiología del Instituto de Investigación Médica “Mercedes y Martín Ferreyra” en Córdoba, Argentina, como Investigador Asistente del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). El proyecto dirigido por el Dr. Bisbal estudia los mecanismos moleculares y celulares encargados de regular la formación y el mantenimiento de la polaridad neuronal, un fenómeno crucial para entender tanto el desarrollo y el funcionamiento normal del sistema nervioso, como así también la patogenia de enfermedades neurodegenerativas. Específicamente, el interés del laboratorio es estudiar los mecanismos celulares que regulan la dinámica, estructura y función del Aparato de Golgi en neuronas y, en particular, su trabajo está dedicado al estudio de los mecanismos que regulan el posicionamiento y la distribución polarizada del Aparato de Golgi y de la vía biosintética en neuronas piramidales de hipocampo en cultivo y su efecto en el desarrollo y mantenimiento del árbol dendrítico.

mbisbal@immf.uncor.edu

See more…

   Dra. Mónica Sanchez

 

Dra. Mónica Silvina Sanchez se graduó como Bioquímica en la Universidad Nacional de Córdoba, Argentina en el año 1995 y en el 2000 obtuvo su Doctorado en Ciencias Químicas en la misma Universidad. Realizó sus estudios post-doctorales en el Centro de Excelencia en Productos y Procesos de la Provincia de Córdoba (CEPROCOR), bajo la tutoría de los Dres. Alfredo Cáceres y Carlos Landa. Actualmente es Investigador Adjunto del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) y realiza su trabajo de investigación en el Laboratorio de Neurobiología del Instituto Mercedes y Martin Ferreyra en Córdoba, Argentina. Actualmente se aboca a estudiar el efecto de rotenona, un compuesto de origen natural ampliamente utilizado como insecticida,  sobre el desarrollo de la polaridad de neuronas de hipocampo de embriones de rata. Teniendo en cuenta los escasos datos existentes sobre el efecto de rotenona en el sistema nervioso central, su trabajo demuestra que el insecticida posee un marcado  efecto neurotóxico en neuronas hipocampales en desarrollo y, lo que es más importante, estudia los mecanismos celulares por los cuales el pesticida afecta el desarrollo de la polaridad neuronal. Por lo tanto, sus hallazgos destacan la importancia de establecer un control riguroso sobre el uso del pesticida para proteger la salud de los      mamíferos.

msanchez@immf.uncor.edu

See more...

               Dr. Nicolás Unsain

Nicolás Unsain graduated as B.Sc. at the School of Natural and Exact Sciences, Universidad Nacional de Córdoba (FCEFyN-UNC). Later, he performed his doctoral thesis with Dr Daniel Masco at the Centro de BiologíaCelular y Molecular (CeBiCeM-UNC) where he obtained his PhD from Universidad Nacional de Córdoba in 2009. During his PhD thesis he studied the role of neurotrophins and their receptors in the induction of neuronal death during prolonged seizures.  

In the year 2009 he obtained a postdoctoral fellowship from the government of Canada to perform postdoctoral studies in the laboratory of Dr Phil A Barker, in the Montreal Neurological Institute, in McGill University. There, he stayed for 5 years studying, among other things, molecular pathways involved in axonal degeneration and the physiology of the so called Death Receptors. 

In mid-2014 he returned to Argentina to start his own laboratory at the Instituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET-UNC). He is currently a Research Associate from CONICET.

Dr Unsain’s main research interest is to decipher molecular mechanisms underlying neuronal axon degeneration, with the hope to understand the pathophysiology of numerous neurodegenerative diseases such as Parkinson’s, Alzheimer, glaucoma, among others.  

nunsain@immf.uncor.edu

See More…

Martín Laboratory

            Dr. Mauricio Martín

El Dr. Mauricio Martín obtuvo su título de grado como Licenciado en Biotecnología en la Facultad de Ciencias Bioquímicas y Farmacéuticas de la Universidad Nacional de Rosario, Argentina y completó sus estudios obteniendo el título de Doctor en Ciencias Bioquímicas en el Instituto de Biología Molecular y Celular de Rosario (IBR) en la misma Universidad. Luego se trasladó a España, donde llevó a cabo una estadía post-doctoral en el Centro de Investigaciones Biológicas (CIB-CSIC) de Madrid. En el año 2005 comenzó sus estudios en neurobiología, analizando los cambios de la composición de lípidos que ocurren en membranas neuronales durante el envejecimiento neuronal, en el laboratorio del Dr. Carlos Dotti en la Fundación Cavalieri Ottolenghi, Università degli Studi di Torino, Italia. En el año 2006 se trasladó con el mismo laboratorio al Flanders Institute of Bitechnology (VIB),Department of Developmental Molecular Genetics and Katholieke Universiteit Leuven en Bélgica, donde estudió el rol de la pérdida de colesterol neuronal en los déficits cognitivos que se producen durante el envejecimiento.

En el año 2011 se desempeñó como científico Investigador en el laboratorio del Dr. Dotti en el Centro de Biología Molecular Severo Ochoa (CBMSO-CSIC-UAM) de Madrid, donde comenzó con una nueva línea orientada a estudiar los cambios epigenéticos que ocurren durante el envejecimiento y que producen defectos de aprendizaje y memoria. En el año 2014 se incorpora al laboratorio de Neurobiología del Instituto de Investigación Médica “Mercedes y Martín Ferreyra” en Córdoba, Argentina, como Investigador Adjunto del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). El proyecto dirigido por el Dr. Martín estudia la relación entre disfunción cerebral durante el envejecimiento, alteraciones epigenéticas y composición de lípidos en membranas neuronales.

mmartin@immf.uncor.edu

See More…

Conde Laboratory

Dra. Cecilia Conde                

 

Dr. Cecilia Conde is an Investigator of the National Council of Scientific and Technical Research (CONICET). She received her degree in Chemical Sciences (1991) at the School of Chemical Sciences - National University of Cordoba, Argentina. She was as a Post-doctoral training in the field of Human Genetics and Molecular Biology, focusing on neuromuscular diseases at the Laboratory of Neurogenetics (1998-2004) - Institute for Medical Research Mercedes y Martín Ferreyra INIMEC - CONICET, Argentina. During this time, she performed brief stays in France (2000, Laboratory of Biochemistry and Molecular Genetics. Hospital Cochin and Hospital Ambroise Pare), USA (2001, Kleberg Cytogenetics Laboratory, Baylor College of Medicine and at the Margaret M. Dyson Vision Research Institute, Weill Cornell Medical College). Her group focuses on the intracellular mechanisms controlling the differential distribution of organelles of the endolysosomal pathway in dendrites of developing and mature neurons.

.

cconde@immf.uncor.edu

See more…

López Laboratory

           Dr. Pablo H. H. López

Dr. Pablo Héctor Horacio Lopez received his Bachelor degree in Clinical Biochemistry at the National University of Córdoba (UNC), Argentina in 1998 and obtained his Ph.D. in Chemical Sciences from the same University in 2002. He emigrated to the Johns Hopkins University, Baltimore, MD-USA to carry out two postdoctoral studies between the years 2003-2009. There, he worked first in the Department of Neurology in the “Development of Experimental Models of Axonal Peripheral Neuropathy” under the supervision of Dr. Kazim A. Sheikh. Then, he studied different physiological aspects of the Myelin-Associated Glycoprotein (MAG), a lectin with a key role in axon-myelin communication, at the Department of Pharmacology and Molecular Neurosciences under the supervision of Dr. Ronald L. Schnaar. At the end of 2009, he returned to the country through the Return home program from the National Agency for Scientific and Technological Promotion and UNC. He is currently an Independent Researcher from the National Council of Scientific and Technical Research (CONICET) and directs a Laboratory at the Ferreyra Institute in Córdoba, Argentina. He also served as Assistant Professor of the 500 Internal Server Error

Internal Server Error

The server encountered an internal error or misconfiguration and was unable to complete your request.

Please contact the server administrator at webmaster@institutoferreyra.org to inform them of the time this error occurred, and the actions you performed just before this error.

More information about this error may be available in the server error log.