BIPARENTAL CARE, PATERNAL ROLE AND THE REINFORCING EFFECTS OF ALCOHOL
Filial ties play an important role in progeny development. Different social experiences and attachment conditions during early development and throughout life can directly affect drug use and abuse. This point becomes relevant considering that interactions between drugs of abuse and social behaviors have led to the hypothesis that the neural circuits involved in the reinforcing effects of these drugs would be shared by those underlying natural reinforcers, including social attachment. The general objective of the project is to analyze, through the use of an animal model, the role of family structure and attachment during early ontogeny, on alcohol reinforcing effects. The realization of this project will allow answering some questions in the current literature allowing to inquire about the specific role that each parent has in parenting and its effects on the subsequent reactivity to alcohol, in both parents and progeny.
PhD and Undergraduate Students
Lucila Mariana Pasquetta
Tesinista. Estudiante de Psicología en la UNC
Facultad de Psicología, Universidad Nacional de Córdoba.
Tesinista. Estudiante de Biología
Facultad de Cs. Ex. Fs. y Nat., Universidad Nacional de Córdoba.
- FONCyT, PICT 2016-2461. Impact of family structure and attachment during early ontogeny of reactivity to alcohol.
- CONSOLIDAR-SECyT, UNC 2018. Early ethanol exposure: learning acquisition with impact on respiratory reactivity and drug sensitization processes (Co-director).
PUBLICATIONS (Last 5 years)
- Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption. Ferreyra E, Pasquetta L, Ramirez A, Wille-Bille A, Molina JC, Miranda- Morales RS. Psychopharmacology (Berl). 2020;237(6):1841-1850. doi: 10.1007/s00213-020-05501-3.
- Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies. Miranda-Morales RS, Aloisio G, Anunziata F, Abate P, Molina JC. Front Behav Neurosci. 2020;14:33. doi: 10.3389/fnbeh.2020.00033
- Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake. Wille-Bille A, Bellia F, Jiménez García AM, Miranda-Morales RS, Addario C, Pautassi RM. Neuropharmacology. 2020;165:107917. doi: 10.1016/j.neuropharm.2019.107917.
- Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, Addario C, Pautassi RM. Prog Neuropsychopharmacol Biol Psychiatry. 2018;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005.
- Effects of ethanol exposure in a familiar or isolated context during infancy on ethanol intake during adolescence. Miranda Morales RS, Haymal OB, Pautassi RM. Developmental Psychobiology. 2016;58(8):968-979. doi: 10.1002/dev.21427
- Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response. Fernández MS, Fabio MC, Miranda-Morales RS, Virgolini MB, De Giovanni LN, Hansen C, Wille-Bille A, Nizhnikov ME, Spear LP, Pautassi RM. Alcohol. 2016;51: 89-100. doi: 10.1016/j.alcohol.2015.11.009.
- Pharmacological characterization of the nociceptin/orphanin FQ receptor on ethanol-mediated motivational effects in infant and adolescent rats. Miranda Morales RS, Pautassi RM. Behavioural Brain Research. 2016;298 (Pt A): 88-96. doi: 10.1016/j.bbr.2015.04.016.