Endosomal traffic and regulation of endocytic processes during neuronal development

Neurons are highly polarized cells that use various mechanisms to initiate, maintain and regulate their biological functions, having up to 10,000 times more cell surface than other cell types, presenting a unique and complex morphology: long processes (axon and dendrites) that are extended from the cell body. There are specific protein delivery mechanisms to these neuronal compartments so that each neuronal domain has the correct molecular composition; the question is how these mechanisms take place in the polarized membrane domains of neurons. The endosomal system ensures the correct targeting of membrane components, internalizing and degrading incorrectly located proteins, or recycling proteins from one domain to another; the endosomes are essential components. Organization and regulation of the endosomal pathway are well studied in different cell systems, such as fungi, fibroblasts, and epithelial cells, but less information is available about this pathway in neuronal cells. This research work is aimed at providing new data about the mechanisms, effectors and dynamics of the components of the endocytic pathway and that regulate endosomal traffic in neurons, their participation in morphological changes, that is, the formation and maintenance of the neuritic growth, as well. Our lab is mainly focused on analyzing the biological role of the protein Smad Anchor for Receptor Activation (SARA) in two main processes: trafficking and cellular signaling, both necessary for intercellular coordination, communication and development.


Dra. Victoria Rozés Salvador

Becario Post-Doctoral de CONICET




-National Agency of Science and Technology Promotion (ANPCyT-FONCyT). Argentina.

-National Agency of Science and Technology Promotion (ANPCyT-FONCyT). Argentina.

-Roemmers Foundation, Argentina International Brain Research Organization (IBRO) - PROLAB 

Publications (last 5 years)

  • Rozés-Salvador V, Wilson C, Olmos C, Gonzalez-Billault C and Conde C. (2020) Fine-tunning the TGFβ signaling pathway by SARA during neuronal development (accepted in Front. Cell Dev. Biol. doi: 10.3389/fcell.2020.550267)

  • Siri S, Rozés-Salvador V, Artur de la Villarmois E, Ghersi MG, Quassollo G, Pérez MF and Conde C. (2020) Decreased Rab11 during neuronal development disrupts dendrite growth, affecting synaptic plasticity and spatial memory formation Biochim Biophys Acta Mol Cell Res. 2020;1867(9):118735
  • Urrutia PJ, Bodaleo F, Bórquez DA, Rozes-Salvador V, Villablanca C, Conde C, Fukuda M and González-Billault C. (2020) Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a (under revision in J Neurosci).
  • Rozés-Salvador V and Conde C. (2019). Participation of Rabs during Neuronal Development and Disease. J Mol Genet Med.13:1 doi: 10.4172/1747-0862.1000397.
  • Rozés Salvador V, Siri S, Musri M and Conde C. (2018) New player in endosomal trafficking: Differential roles of Smad Anchor for Receptor Activation (SARA) protein. Mol Cell Biol. pii: e00446-18.
  • Mestres I, Chuang JZ, Calegari F, Conde C and Sung CH. SARA regulates neuronal migration during neocortical development through L1 trafficking. Development 2016, 143: 3143-53.
  • Arias C, Siri S and Conde C. Involvement of SARA in axon and dendrite growth. PLoS One 2015, 10: e0138792
  • Quassollo G, Wojnacki J, Salas DA, Gastaldi L, Marzolo MP, Conde C, Bisbal M, Couve A, Cáceres A. A RhoA signaling pathway regulates Golgi outpost formation. Curr Biol 2015, 25: 971-982.