APPETITE FOR SODIUM: MECHANISMS, SENSORS, NEURAL CIRCUITS INVOLVED IN ITS REGULATION AND ITS EFFECT ON PERINATAL PROGRAMMING
The main dysfunctions in the balance of sodium and body water are classically recognized as hyponatremia and hypernatremia because sodium is the determining ion of the osmolarity of the extracellular fluid. Both disorders contribute to morbidity and mortality and are highly prevalent in critically ill patients. Epidemiological studies have indicated that hyponatremia occurs in approximately 1-2% of hospitalized patients. This alteration is defined as a serum sodium concentration lower than 135 mmol / l; its presence indicates an excess of body water in relation to the body sodium content. On the other hand, antagonistic or hypertonic states are associated with the development of cardiovascular diseases such as hypertension in genetically predisposed individuals. Consequently, the stability of osmolarity / natremia is essential for the survival of organisms. Changes in osmolarity / natremia cause changes in cell volume and are detected at the brain level by different mechanisms that initiate the sequence of corrective actions, such as modulating thirst and sodium consumption called “appetite for sodium” (AS). In this context, our studies try to address the following questions:
-What mechanisms are involved in modulating the appetite for sodium? -What are the detection systems involved in initiating the appetite for sodium? -Does the osmosensitive channel TRPV1 participate in the stimulation of the appetite for sodium? -How and when does the interaction between the excitatory and inhibitory systems of the appetite for sodium occur?
These works will allow us to understand the regulatory mechanisms that organisms have in order to achieve an adequate body sodium balance, regulating the appearance of appetitive behavior in relation to variations in body sodium status. In addition, the study of the antagonistic interaction between angiotensinergic brain circuits, stimulators of sodium appetite, located mainly in the lamina terminalis with the inhibitory serotonergic circuit (5HT) at the brainstem level, would provide more assertive strategies in pursuit of treatment of pathologies where there is an alteration of the hydrosaline balance with its consequent alteration in the natremia, blood volume and in many cases also the alteration of the arterial pressure. Likewise, we are currently studying the physiological and cardiovascular impact of high sodium intake in pregnant females on the progeny.
Andrea Godino:
Adjunct Researcher at CONICET, in the Hydrosaline Balance and Hypertension Laboratory of the M. and M. Ferreyra Medical Research Institute (INIMEC).
Assistant Professor semi-certified by competition (RD 1346/16) in the subject of Experimental Psychobiology at the Faculty of Psychology of the UNC. Associate Professor: Juan Carlos Molina. Competition August 2016.
Estudiantes de doctorado
Cintia Porcari
PhD in Biology.
Directors: Laura Vivas and Andrea Godino.
Conicet Scholar
cporcari@immf.uncor.edu
Agustina Macagno
PhD in Neuroscience
Director Andrea Godino. Co-director Agustin Anastasía.
Foncyt Scholar
Undergraduate students.
Valetín Cabrera
Bachelor's degree student in Psychology, UNC.
Director: Andrea Godino.
Lucas Martinez
Bachelor's degree student in Psychology, UNC.
Director: Andrea Godino.
SUBSIDIOS
- FONCyT
- SECYT
- ROEMMERS.
PUBLICACIONES (ÚLTIMOS 5 AÑOS)
- Porcari C.Y. a, Debarba L.K. b,Amigone J.Lf, Caeiro X.E.a, Reis L.C.e, Cunha T.M.b, Mecawi A.S.g, Elias, L.L.b, Antunes-Rodrigues J.b, Vivas L.ac *and Godino A.ad+*. (autor corresponsal). Brain osmo-sodium sensitive channels and the onset of sodium apetite. Horm Behav. 2020 Feb;118:104658. doi: 10.1016/j.yhbeh.2019.104658. Epub 2020 Jan 7
- Cintia Yamila Porcaria, Iracema Gome Araújob, Lilia Urzedo-Rodriguesc, Laurival Antonio De Luca Jrc, José Vanderlei Menanic, Ximena Elizabeth Caeiroa, Hans Imbodend, José Antunes-Rodriguese, Luís Carlos Reisb, Laura Vivasa,f, Andrea Godino,*, André Souza Mecawi*. *Contribución equivalente. Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus. J Neuroendocrinol. 2019 Apr;31(4):e12703. doi: 10.1111/jne.12703.
- Godino A and Renard MG (2018). Effects of alcohol and psychostimulants on the vasopressin system: behavioral implications. Review article. J Neuroendocrinol. 2018 May 26:e12611. doi: 10.1111/jne.12611
CAPÍTULOS DE LIBROS:
- Vivas L, Godino A, Dalmasso C, Caeiro X, Macchione F, Cambiasso MJ. Chapter IX: Neurochemical circuits subsering fluid balance and baroreflex: a role for serotonin, oxytocin and gonadal steroids. “Neurobiology of Body Fluids Homeostasis: Transduction and Integration” Taylor & Francis Group, LLC. Eds.: L. DeLuca, A.K. Johnson and J.V. Menani, Pags.: 105-129, 2013.