Currently, the Laboratory is developing 3 lines of research that focus on the study of different homeostatic models of regulation of the hydro-electrolyte and cardiovascular balance.

  • Project 1: addresses the study of brain mechanisms and systems involved in perinatal programming models of osmoregulation. For example, how the high-salt intake of mothers can modify the intake and excretion of water and sodium of the progeny.
  • Project 2: investigates the neuromodulation mechanisms, circuits and systems that underlie the existing sexual dimorphism in the arterial blood pressure regulation system using different models of hypertension.
  • Project 3: analyzes the mechanisms and the participation and / or interaction of different brain neurotransmission and peptide systems in the regulation of thirst, appetite for salt and renal excretion of water and sodium. We study how specific cells and pathways detect changes in osmolarity in order to arouse thirst.

Techniques used:

For the study of the hodological, neurochemical and functional characteristics of the systems that underlie the control of hydrosaline and cardiovascular homeostasis, different techniques are used in different study animal models: double and triple immunohistochemical technique, retrograde pathway markers, immunoblot, RT PCR, electrophysiological techniques (Patch clamp), transgenic animals, blood pressure recording techniques, tissue cultures, etc.



Biol. Lihue Gonzalez

Biological Sciences PhD student, UNC.

CONICET doctoral fellow

Directors: Laura Vivas and Andrea Godino

Biol. Agustina Macagno

Doctoral student in Neuroscience, UNC.

Foncyt doctoral fellow

Director: Andrea Godino and Co-director Agustín Anastasía.


Dr. Aranza Wille-Bille

CONICET Postdoctoral Fellow.

Director Laura Vivas and Co-director Andrea Godino


Valentin Cabrera

Student of the Degree in Psychology

Director of the final work: Dra Andrea Godino.

Lucas Martinez

Student of the Degree in Psychology

Director of the final work: Dra Andrea Godino.




  1. Margatho LO, Porcari CY, Macchione AF, Souza GD, Caeiro XE, Antunes-Rodrigues J, Vivas L, Godino A. Temporal dissociation between sodium depletion and sodium appetite appearance: Involvement of inhibitory and stimulatory signals. Neuroscience 297: 78-88, 2015. Impact Factor: 3,357

  2. Macchione AF, Beas C, Dadam FM, Caeiro XE, Godino A, Ponce LF, Amigone JL, Vivas L. Early free access to hypertonic NaCl solution induces a long-term effect on drinking, brain cell activity and gene expression of adult rat offspring. Neuroscience: 298: 120-136, 2015. Impact Factor: 3,357

  3. Fabio MC, Vivas LM, Pautassi RM. Prenatal ethanol exposure alters ethanol-induced Fos immunoreactivity and dopaminergic activity in the mesocorticolimbic pathway of the adolescent brain. Neuroscience 301, pp. 221-234, 2015. Impact Factor: 3,357

  4. Casarsa, Bs; Marinzalda, Ay; Marchese, N; Peace, Cma; Vivas, L. Baiardi G. and C. Bregonzio. A Previous History Of Repeated Amphetamine Exposure Modifies Brain Angiotensin II At1 Receptor Functionality. Neuroscience 307: 1–13, 2015. Impact Factor: 3,357

  5. Dalmasso, C.a, Antunes-Rodrigues, J., Vivas, L., De Luca, L.A., Jr. Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake. Physiol and Behav. 151: 494-501, 2015. Impact Factor: 3.19

  6. Godino A, Abate P, Amigone JL, Vivas L, Molina JC. Prenatal binge-like alcohol exposure alters brain and systemic responses to reach sodium and water balance. Neuroscience 311: 92–104, 2015. Impact Factor: 3,357

  7. Dadam FM, Cisternas CD, Macchione AF, Godino A, Antunes-Rodrigues J, Cambiasso MJ, Vivas LM, Caeiro XE. Sex chromosome complement involvement in angiotensin receptor sexual dimorphism. Mol Cell Endocrinol. 447: 98–105, 2017. Impact factor: 3,859

  8. Silva, M., Lúcio-Oliveira, F., Mecawi, A, Almeida, L., Ruginsk, S., Greenwood, MP, Greenwood, M., Vivas, L, Elias, LK, Murphy, D., Antunes- Rodrigues, J. Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring. Physiological Reports 5 (6) e13210 DOI: 10.14814 / phy2.13210, 2017.

  9. Villegas-Gabutti CM, Pennacchio G, Vivas L, Jahn GA, Soaje M. Role of Oxytocin on Prolactin Secretion During Late Pregnancy. Neuroendocrinology. 2017 Aug 27. doi: 10.1159 / 000480669. [Epub ahead of print] PubMed PMID: 28848175.

  10. The effect of increased NaCl intake on rat brain endogenous µ-opioid receptor signaling. Dadam, F., Zádor F., Caeiro X., Szűcs E., Erdei A., Samavati, R., Gáspár R. Borsodi A., and L. Vivas. J. Neuroendocrinol, 2018; 30: e12585.

  11. Cintia Yamila Porcari Iracema Gome Araújo Lilia Urzedo-Rodrigues Laurival Antonio De Luca Jr José Vanderlei Menani Ximena Elizabeth Caeiro Hans Imboden José Antunes-Rodrigues Luís Carlos Reis Laura Vivas, Andrea Godino * André Souza Mecawi *. Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus. J Neuroendocrinol. 2019; e12703. * Equal contributions.

  12. Lopes-Menezes VC, Dos-Santos RC, Felintro V, Monteiro LRN, Paes-Leme B, Lustrino D, Casartelli EA, Vivas L, Mecawi AS, Reis LC. Acute body sodium depletion induces skin sodium mobilization in female Wistar rats. Exp Physiol. 2019 Dec; 104 (12): 1754-1761.doi: 10.1113 / EP087998. Epub 2019 Oct 24. PubMed PMID: 31553087.

  13. Porcari CY, Debarba LK, Amigone JL, Caeiro XE, Reis LC, Cunha TM, Mecawi AS, Elias LL, Antunes-Rodrigues J, Vivas L *, Godino A *. Brain osmo-sodium sensitive channels and the onset of sodium appetite. Horm Behav. 2020 Feb; 118: 104658. doi: 10.1016 / j.yhbeh.2019.104658. Epub 2020 Jan 7. PubMed PMID: 31874139. * Equal contributions.

REVIEW WORKS (2012-2017)

  1. Mecawi, A., Macchione, AF, Nunez, P., Perillan, C., Reis, LC, Vivas, L., Arguelles, J. Developmental programming of thirst and sodium appetite Neuroscience and Biobehavioral Reviews 51 (2015) 1–14 . Impact factor: 10.2.
  2. Vivas, L., Dadam, F.M., Caeiro, X.E. Sex differences in body fluid homeostasis: Sex chromosome complement influences on bradycardic baroreflex response and sodium depletion induced neural activity. Review. Physiol Behav. 2015, Dec 1; 152 (Pt B): 416-21. Impact factor: 3.16


1-Vivas L, Godino A, Dalmasso C, Caeiro X, Macchione F, Cambiasso MJ. Chapter IX: Neurochemical circuits subsering fluid balance and baroreflex: a role for serotonin, oxytocin and gonadal steroids.  “Neurobiology of Body Fluids Homeostasis: Transduction and Integration” Taylor & Francis Group, LLC. Eds. : L. DeLuca, A.K. Johnson and J.V. Menani, Pags.: 105-129, 2013. ISBN 9781466506930

2- Antunes-Rodrigues, J; Lucila K Elias K., Margaret de Castro,  De Luca, A.L.; Vivas, L. Menai, J. Cap 75 Controle Neuroendocrino do Balanço hidrolectrolitico, 1181-1198. Fisiología Margarida de Mello Aires. 4ra Edición, Guanabara Koogan, Rio de Janeiro, 2012. ISBN: 978-85-277-2100-4.