STUDY OF THE MECHANISMS INVOLVED IN THE INCREASE OF THE PRODUCTION OF THE AMYLOID PEPTIDE β (ABETA) INDUCED BY THE DEPOSITION OF THE FAB: PATHOGENIC MECHANISM OF POSITIVE FEEDBACK IN ALZHEIMER’S DISEASE.
The laboratory’s general area of interest is the study of the biological and molecular mechanisms through which the Abeta peptide induces its neurodegenerative toxic effects in the brain of patients with Alzheimer’s disease. In particular, we study aspects related to the production of Abeta (amyloidogenesis), its modulating factors and its relationship with the trafficking of certain proteins involved. For them we use cell line cultures and primary hippocampal cells, and we use biochemical and molecular biology techniques.
The advancement of knowledge about this phenomenon of Abeta deposition and its modulation would have a great impact on the development of therapeutic strategies with the aim of treating or preventing Alzheimer’s disease.
WORKGROUP:
Biologist Magadalena Antonino
CONICET Doctoral Fellow
SUBSIDIES
- Conicet, Foncyt and Secyt.
PUBLICATIONS (LAST 5 YEARS)
- Sigwald EL, Bignante EA, de Olmos S, Lorenzo A. (2019) FEAR-CONTEXT ASSOCIATION DURING MEMORY RETRIEVAL REQUIRES INPUT FROM GRANULAR TO DYSGRANULAR RETROSPLENIAL CORTEX. Neurobiology of Learning and Memory, 163: 107036. doi: 10.1016 / j.nlm.2019.107036.
- Bignante EA and Lorenzo A. Aging. (2018) APP SIGNALING IN ALZHEIMER’S DISEASE. doi: 10.18632 / aging.101641.
- Lopez Rivilli MJ, Turina ADV, Bignante EA, Molina VA, Moyano EL, Perillo MA, Briñon MC. (2018) SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF PYRAZOLO [4,3- C] QUINOLINONES AS HIGH AFFINITY GABAA-R LIGANDS AND POTENTIAL ANXIOLYTICS. Bioorganic & Medicinal Chemistry, 26: 3967-3974.
- Bignante EA, Ponce N, Heredia MF, Musso J, Krawczyk MC, Millán J, Pigino G, Inestrosa N, P Boccia MM and Lorenzo A. (2018) APP / GO PROTEIN GΒΓ COMPLEX SIGNALING MEDIATES AΒ DEGENERATION AND COGNITIVE IMPAIRMENT IN ALZHEIMER´ S DISEASE MODELS. Neurobiology of Aging. 64: 44-57.